3-Carboxyphenylboronic acid, also known as (3-boronophenyl)formic acid, is an aromatic boronic acid intermediate identified by CAS 25487-66-5. Its molecular formula is C7H7BO4, and its calculated molecular weight is 165.94 g/mol. The molecule contains both a carboxylic acid group and a boronic acid group, making it useful for synthetic routes that require complementary reactivity.
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This guide explains what the compound is, how it is commonly used, which specifications matter during purchasing, and how buyers can evaluate a suitable supplier. Because commercial grades and manufacturing processes can differ, I recommend confirming the current specification, analytical data, packaging, and delivery schedule before placing an order.
This guide is intended for pharmaceutical and fine-chemical companies, medicinal chemistry teams, process development laboratories, contract research organizations, and procurement specialists sourcing 3-carboxyphenylboronic acid. It is also relevant to buyers comparing laboratory quantities with larger project-scale requirements. The most important purchasing decisions usually involve identity, purity, analytical documentation, batch consistency, and supply continuity.
Researchers may need a small quantity for route screening, while process teams may require repeatable batches for scale-up studies. These two use cases should not automatically be handled with the same purchasing specification. I suggest defining the intended reaction, required purity, expected annual demand, and documentation package before requesting a quotation.
3-Carboxyphenylboronic acid is a meta-substituted benzoic acid derivative in which the boronic acid functionality is positioned at the 3-position relative to the carboxyl group. The aromatic ring provides a stable structural framework, while the two acidic functional groups influence polarity, hydrogen bonding, and reaction behavior. The boronic acid group can participate in carbon–carbon bond-forming chemistry, while the carboxylic acid group can support coupling, salt formation, or further functional-group transformation.
The compound should be treated as a multifunctional organic intermediate rather than as a finished active pharmaceutical ingredient. Its behavior in a reaction depends on solvent, pH, temperature, concentration, catalysts, protecting-group strategy, and the identity of the reaction partner. For that reason, a catalog description alone is not a substitute for reaction-specific development work.
| Item | Information |
|---|---|
| Product name | 3-Carboxyphenylboronic acid |
| CAS number | 25487-66-5 |
| Molecular formula | C7H7BO4 |
| Calculated molecular weight | 165.94 g/mol |
| Functional groups | One carboxylic acid and one boronic acid group |
Buyers should also request the appearance description, assay method, water content where relevant, residual solvent information, and impurity profile. A certificate of analysis should identify the tested batch and the analytical methods used. If the material is intended for a regulated development program, the documentation requirements may be broader than those for exploratory research.
3-Carboxyphenylboronic acid is generally purchased as a research or synthesis-grade solid, but the practical specification can vary by supplier and application. The key difference is not always a different chemical form; it may instead be the purity target, packaging size, analytical package, or quality-control approach. Buyers should avoid assuming that two products with the same CAS number have identical impurity profiles or identical performance in a sensitive synthesis.
For early route screening, a standard research-grade material may be sufficient if identity and assay are clearly documented. For process development, buyers may request a defined assay target, chromatographic purity, water content, residual solvent limits, and batch-to-batch comparison. If the material will enter a more controlled pharmaceutical intermediate supply chain, the purchasing specification should be agreed before production rather than after delivery.
Common analytical tools for identity and quality review may include HPLC, NMR, mass spectrometry, and elemental or water analysis, depending on the supplier’s quality system and customer requirements. I recommend asking which method is used for each reported result, rather than reviewing only a single purity number. The actual acceptance criteria should be connected to the customer’s reaction and downstream process.
The main application value of 3-carboxyphenylboronic acid comes from its ability to serve as a bifunctional building block. The boronic acid group is commonly considered in palladium-catalyzed cross-coupling design, including Suzuki-type transformations with suitable electrophilic partners. The carboxylic acid group can remain available for later derivatization or be incorporated into an amide, ester, or other functionalized product.
In medicinal chemistry, this structure can help connect an aromatic boronic acid fragment with a second pharmacophore or linker. In process chemistry, the same intermediate may be evaluated as part of a convergent route, although reaction robustness and impurity control must be demonstrated experimentally. In materials or sensor research, the two functional groups may provide useful attachment points, but suitability depends strongly on the target design and formulation conditions.
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Solubility is an important practical consideration. Aromatic carboxylic and boronic acids may show solvent- and pH-dependent behavior, so I recommend checking the intended reaction solvent and concentration during laboratory evaluation. A supplier should not be expected to guarantee performance in every formulation unless the relevant conditions have been defined and tested.
Before requesting a quotation, prepare a concise product requirement covering CAS number, intended use, target quantity, preferred purity, packaging, delivery destination, and documentation needs. This reduces the risk of comparing quotations that are based on different quality assumptions. It also allows the supplier to identify whether the request is for laboratory supply, development-scale material, or a longer-term manufacturing program.
Check the product name, CAS number, molecular formula, molecular weight, and structural position of the substituents. The “3-carboxy” designation is important because positional isomers can have different reactivity and analytical characteristics. Ask for a current specification sheet and a representative or batch-specific certificate of analysis.
Do not use “high purity” as the only requirement. State whether you need a minimum assay, a chromatographic purity threshold, limits for specific impurities, water information, or residual solvent data. For an initial screening order, a target such as 1 g or 10 g may be practical, while larger project requirements should be discussed in kilograms only after the specification and production route are aligned.
Compare more than the unit price. Confirm available stock, production lead time, minimum order quantity, packaging configuration, shipping conditions, payment terms, and the validity period of the quotation. If the material will be reordered, ask whether the supplier can support consistent specifications across multiple batches.
A capable supplier should respond clearly to questions about analytical methods, packaging, sample availability, and document formats. Technical communication is especially important when a buyer needs custom specifications or a nonstandard quantity. I recommend recording all agreed requirements in the purchase order or technical agreement.
The cost of 3-carboxyphenylboronic acid can vary with purity, quantity, packaging, production scheduling, testing requirements, and shipping destination. Small laboratory packs often have a higher price per gram because testing, handling, packaging, and order processing are distributed over a smaller amount of material. Larger quantities may improve the unit economics, but only when the buyer has confirmed stability, demand, and storage requirements.
Minimum order quantity is not a universal chemical property; it is a commercial and manufacturing variable. A supplier may offer a small pack for evaluation and a separate quotation for development or production quantities. Lead time can also change according to inventory status and whether a new batch must be manufactured, so buyers should request a written estimate for the exact quantity and specification.
At Maison Chemical, I approach 3-carboxyphenylboronic acid sourcing as a specification-matching process rather than a simple catalog transaction. We can discuss the intended application, target quantity, purity expectations, packaging needs, and analytical documents before preparing a quotation. This helps buyers select a material that fits their actual project stage.
Our support can cover laboratory evaluation quantities, development-stage requirements, and discussions for repeat supply, subject to product availability and agreed specifications. For each inquiry, I recommend sharing the CAS number, required quantity, target delivery date, destination, and any special quality requirements. With that information, Maison Chemical can provide a more relevant commercial and technical response.
3-Carboxyphenylboronic acid CAS 25487-66-5 is a versatile pharmaceutical and fine-chemical intermediate because its boronic acid and carboxylic acid groups enable different synthetic options. The right grade depends on whether you are conducting early discovery, optimizing a process, or planning repeat supply. A responsible purchase decision should be based on verified identity, defined quality requirements, suitable packaging, and realistic delivery conditions.
To begin, prepare your required quantity, purity target, application, destination, and documentation list. Then contact Maison Chemical for a product discussion and quotation based on those requirements. We can help you evaluate the appropriate supply option before you commit to a larger order.
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