2-Fluoro-6-methoxyphenylboronic acid, identified by CAS 78495-63-3, is an aryl boronic acid used primarily as a building block in palladium-catalyzed cross-coupling chemistry. Its molecular formula is commonly listed as C7H8BFO3, with a molecular weight of approximately 169.95 g/mol. The compound combines a boronic acid group with fluoro and methoxy substituents, allowing chemists to introduce a substituted aromatic ring into research compounds and advanced intermediates. In this guide, I explain the key specification points, application considerations, purchasing questions, and supplier evaluation steps that I recommend for B2B sourcing.
This guide is intended for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, custom synthesis companies, process development groups, and chemical distributors. It is also relevant to procurement professionals who need to compare several suppliers of specialty organic boronic acids. Because commercial specifications can vary by manufacturer, buyers should use the information below as a technical purchasing framework rather than as a substitute for a current certificate of analysis.
For a reliable sourcing decision, I recommend confirming identity, assay, water content, residual solvents, analytical data, packaging, and delivery capability before placing an order. These details become increasingly important when a material is required for repeated reaction development or a regulated documentation workflow. A supplier that provides only a product name and nominal purity may not provide enough information for scale-up decisions.
2-Fluoro-6-methoxyphenylboronic acid belongs to the class of aryl boronic acids. The boronic acid group is chemically useful because it can participate in Suzuki–Miyaura coupling with suitable aryl or heteroaryl halides under appropriate reaction conditions. The fluoro substituent can influence the electronic character of the aromatic ring, while the methoxy group contributes a different electronic and steric profile.
These structural features make the compound useful when a synthesis requires a substituted phenyl fragment rather than an unsubstituted aryl group. However, the exact performance of the reagent depends on reaction partners, catalyst system, base, solvent, temperature, concentration, and work-up method. I therefore recommend treating this material as a project-specific building block instead of assuming that one standard procedure will work for every application.
| Item | Reference information | Buyer verification point |
|---|---|---|
| Product name | 2-Fluoro-6-methoxyphenylboronic acid | Confirm the positional isomer on the quotation and COA |
| CAS number | 78495-63-3 | Check that the CAS number matches the structure supplied |
| Molecular formula | C7H8BFO3 | Review formula and molecular weight against analytical data |
| Molecular weight | Approximately 169.95 g/mol | Use the supplier’s controlled specification for calculations |
A suitable commercial specification should separate identity requirements from quality and handling requirements. Identity may be supported by proton NMR, carbon NMR, fluorine NMR where applicable, mass spectrometry, and chromatographic data. The supplier should identify the analytical methods used and provide results for the actual batch rather than only a general product description.
Assay is commonly reported as a percentage, but buyers should not assume that every supplier uses the same method or acceptance limit. I recommend requesting the assay method, chromatographic purity, water content, residual solvent profile, and appearance description in writing. If the material is intended for a sensitive coupling reaction, the buyer may also wish to discuss boronic acid stability, decomposition observations, and batch-to-batch consistency.
Storage instructions should always follow the supplier’s SDS and product-specific recommendations. As a procurement precaution, I may ask whether refrigerated storage, such as 2–8 °C, is recommended for the supplied batch, but I would not impose that condition without reviewing the manufacturer’s documentation. The appropriate storage arrangement can depend on packaging, stability data, and the intended holding period.
The main application of 2-Fluoro-6-methoxyphenylboronic acid is as an aryl donor in cross-coupling synthesis. It can be considered when a target molecule requires a 2-fluoro-6-methoxyphenyl substituent. Potential users include medicinal chemistry teams preparing analogues, process chemists developing routes to advanced intermediates, and custom synthesis organizations supporting discovery programs.
If you want to learn more, please visit our website Maison Chemical.
Its value is not limited to the reaction itself. A defined substituted aryl building block can help a research team evaluate structure–activity relationships, explore electronic effects, and modify steric characteristics within a compound series. These benefits are project-dependent, so I recommend confirming the intended transformation and scale before selecting the material grade or order quantity.
The price of this type of specialty intermediate can vary according to purity, synthesis route, batch size, packaging, testing requirements, and whether the product is held in stock. A small research pack usually carries a higher cost per gram than a larger project quantity because manufacturing and analytical costs are distributed over less material. I recommend comparing the total delivered cost per gram or per kilogram rather than comparing only the headline unit price.
Minimum order quantity should be discussed early, particularly when a buyer needs a non-standard assay, special packaging, or additional analytical testing. Lead time may also differ between an in-stock batch and a made-to-order batch. For planning, I ask suppliers to quote three elements separately: available stock, standard replenishment time, and an estimated production lead time for larger quantities.
Buyers should also clarify whether the quoted lead time includes quality release, export documentation, and transportation. A low price is less useful if the material cannot arrive within the project schedule or if required documents are delivered late. Where the synthesis is time-sensitive, I recommend requesting a retained sample policy and a clear procedure for handling out-of-specification concerns.
When evaluating a supplier, I look beyond product availability. The supplier should demonstrate that it understands the difference between supplying a catalog chemical and supporting a repeat B2B procurement program. Consistent batch records, responsive technical communication, suitable packaging, and realistic delivery commitments are all important indicators of supply quality.
At Maison Chemical, I approach this product as a specialty organic boronic acid requiring clear technical communication and controlled purchasing information. We can discuss product identity, target quantity, documentation needs, packaging expectations, and delivery planning before quotation. Where a buyer has a specific reaction or scale-up requirement, I recommend sharing the intended use so the proposed specification can be reviewed against the project rather than treated as a generic catalog request.
For buyers seeking 2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3, the right sourcing decision depends on more than the chemical name and nominal price. I recommend confirming the exact isomer, reviewing batch-specific analytical data, matching the specification to the intended coupling reaction, and comparing suppliers on documentation, MOQ, lead time, and continuity of supply. These steps reduce the risk of receiving a material that is unsuitable for the planned synthesis or difficult to qualify internally.
To begin an inquiry with Maison Chemical, prepare the required quantity, target purity, delivery destination, preferred packaging, and documentation requirements. I can then help structure a practical quotation request for laboratory evaluation, route development, or larger project supply. This approach gives procurement and technical teams a clearer basis for comparing options and progressing toward a dependable supply arrangement.
Contact us to discuss your requirements of 2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3. Our experienced sales team can help you identify the options that best suit your needs.
Comments
Please Join Us to post.
0