3,5-Difluorophenylboronic Acid CAS 156545-07-2: Properties, Uses, and Storage Guide

3,5-Difluorophenylboronic acid, CAS 156545-07-2, is an aromatic boronic acid used primarily as a fluorinated building block in organic synthesis, especially palladium-catalyzed Suzuki–Miyaura coupling. Its molecular formula is C₆H₅BF₂O₂, and its calculated molecular weight is approximately 157.91 g/mol. For reliable handling, I recommend verifying the current certificate of analysis, assay, water content, packaging, and storage instructions for each production lot before use.

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This guide explains the compound’s basic properties, common applications, material and specification options, purchasing considerations, and practical storage controls. It is intended for pharmaceutical, agrochemical, specialty chemical, and research organizations evaluating 3,5-Difluorophenylboronic acid for laboratory or manufacturing workflows.

Who This Guide Is For

I have prepared this guide for chemists, procurement teams, process development groups, and quality departments sourcing 3,5-Difluorophenylboronic acid in development or commercial quantities. It is particularly relevant when a project requires a difluorinated aromatic fragment for carbon–carbon bond formation. The information can also help buyers compare product documentation and supplier support before issuing an inquiry.

Because boronic acids can behave differently under varying moisture, temperature, and reaction conditions, users should treat general product information as a starting point rather than a replacement for project-specific validation. Your laboratory or manufacturing team should confirm the material against its current technical documents and internal safety procedures.

Basic Concept and Chemical Context

3,5-Difluorophenylboronic acid contains a boronic acid group attached to a benzene ring with fluorine substituents at the 3- and 5-positions. The boronic acid functionality is valuable because it can participate in cross-coupling chemistry with suitable aryl or vinyl halides. The two fluorine atoms modify the electronic character and lipophilicity of the aromatic ring, which can be useful when designing molecules with specific structure–property targets.

The compound is generally handled as an organic boronic acid intermediate rather than as a final active ingredient. Its principal value is synthetic flexibility: the boronic acid group can be used to introduce a substituted aryl unit into a larger molecular structure. Actual reactivity depends on the reaction partner, catalyst system, base, solvent, temperature, concentration, and water exposure.

Reference Identification Data

The molecular formula and molecular weight are useful for reaction calculations, inventory management, and analytical method setup. They should not be used alone to define commercial quality. For purchasing decisions, I recommend reviewing assay, identity data, residual solvent information, water content, impurity profile, and appearance requirements stated in the applicable specification.

Types, Material Options, and Key Specifications

In practice, buyers may encounter this product in different commercial formats, including research-scale solid material, larger packaged solid material, or a customer-specific grade supported by an agreed specification. The correct option depends on the intended reaction scale, analytical requirements, delivery schedule, and quality system. A supplier should confirm which formats are currently available rather than assuming that every grade is stocked.

Specifications Buyers Should Review

• Identity: Confirm the product name, CAS number, molecular formula, and analytical identity results.
• Assay or purity: Establish the required purity level according to the reaction and downstream application.
• Appearance: Define acceptable color and physical form where appearance is relevant to receiving inspection.
• Water content: Moisture can affect weighing, storage stability, and reaction reproducibility, so this parameter may require attention.
• Residual solvents: Review the applicable testing approach when the material enters a regulated or tightly controlled process.
• Lot documentation: Request a certificate of analysis and, when required, a safety data sheet and technical specification.
• Packaging: Confirm the container type, net weight, labeling, and protection against moisture during shipment.

For early-stage research, a standard analytical specification may be sufficient. For process development or regulated manufacturing, the buyer may need a defined impurity profile, change-notification expectations, batch traceability, and a documented supply arrangement. These requirements should be agreed before the first purchase to avoid later qualification delays.

Application Matching: Where Is It Used?

The most recognized application of 3,5-Difluorophenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling. In a suitable reaction system, the boronic acid can couple with an aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. This makes it relevant to the preparation of fluorinated intermediates for medicinal chemistry, pharmaceutical research, agrochemical discovery, and specialty molecule development.

Its use is not limited to one product category, because the difluorophenyl fragment may be incorporated into different molecular scaffolds. Fluorinated aromatic groups are often considered during lead optimization and property design, but the final effect depends on the complete molecular structure. I recommend confirming the intended transformation through small-scale experiments before committing to larger material volumes.

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Typical Project Scenarios

• Preparation of substituted biaryl intermediates through palladium-catalyzed cross-coupling.
• Medicinal chemistry campaigns requiring a 3,5-difluorophenyl structural fragment.
• Route scouting for pharmaceutical or agrochemical intermediates.
• Custom synthesis programs where a defined aromatic boronic acid is required.
• Process research involving scale-up of a previously validated coupling reaction.

Reaction success depends on more than the boronic acid itself. Catalyst selection, base compatibility, substrate sensitivity, boronic acid stability, mixing, and purification strategy can all influence yield and impurity formation. Therefore, product selection and process optimization should be managed together rather than treated as separate purchasing and chemistry decisions.

Selection Framework for Buyers

I recommend using a four-part evaluation framework: technical fit, documentation, supply capability, and commercial suitability. First, match the required purity and physical format to the reaction stage. Second, check whether the supplier can provide consistent lot documentation and answer questions about packaging, storage, and change control.

Third, assess supply continuity instead of focusing only on the first quotation. Ask whether the material is manufactured or sourced, whether repeat batches can be supported, and what information is available for production planning. Fourth, compare the total purchasing requirement, including minimum order quantity, lead time, packaging, shipping conditions, and any testing or customization charges.

Pricing, MOQ, and Lead-Time Considerations

Pricing for 3,5-Difluorophenylboronic acid can vary according to purity, order quantity, packaging, production route, testing requirements, and market availability. I do not recommend relying on a generic catalog price when planning a manufacturing program. Instead, provide the supplier with the required quantity, target specification, delivery location, and expected purchasing frequency.

Minimum order quantity may differ between an in-stock laboratory pack and a production-oriented batch. Lead time can also change when the supplier must arrange fresh production, additional analytical testing, special packaging, or export documentation. Requesting a formal quotation with validity, delivery terms, packing details, and documentation scope creates a clearer basis for comparison.

Storage and Handling Guide

Store 3,5-Difluorophenylboronic acid in a tightly closed, clearly labeled container in a cool, dry location, following the supplier’s SDS and product-specific instructions. Protecting the material from unnecessary moisture, heat, and contamination is a prudent general practice for boronic acid intermediates. The exact storage temperature and shelf-life should be confirmed from the current product documentation rather than assumed.

When opening the package, use appropriate personal protective equipment and work in accordance with your site’s chemical hygiene procedures. Minimize repeated exposure of the full container to ambient humidity by removing only the quantity needed for the operation and promptly resealing the original package. If the material shows an unexpected change in appearance or performance, quarantine the lot and consult the supplier before use.

Common Storage Mistakes

• Leaving the container open during extended weighing or preparation activities.
• Transferring the product into an unmarked container without preserving lot information.
• Storing it beside incompatible chemicals or in an area with uncontrolled humidity.
• Using material beyond the internal retest or shelf-life period without documented evaluation.
• Accepting a shipment without checking packaging integrity and product identification.

How Maison Chemical Supports Sourcing

At Maison Chemical, I approach this product as part of a broader organic boronic acid supply requirement. We can discuss the intended application, target quantity, purity expectations, packaging preference, documentation needs, and delivery schedule before recommending a supply route. This helps align the commercial quotation with the actual requirements of your laboratory, process team, or purchasing department.

For qualified inquiries, our support can include product identification review, specification communication, quotation preparation, packaging coordination, and shipment planning. Where a project requires tighter control, we can also discuss lot documentation and customer-specific quality requirements subject to technical and production feasibility. Availability, MOQ, lead time, and documentation should be confirmed for each inquiry.

Key Takeaways

• 3,5-Difluorophenylboronic acid is an aromatic boronic acid identified by CAS 156545-07-2.
• Its formula is C₆H₅BF₂O₂, with a calculated molecular weight of approximately 157.91 g/mol.
• Its main value is as a fluorinated aryl building block for suitable cross-coupling and intermediate synthesis applications.
• Buyers should evaluate purity, water content, documentation, packaging, MOQ, lead time, and repeat-batch support.
• Storage should follow the current SDS and supplier instructions, with protection from moisture, heat, and contamination.

Conclusion and Next Steps

3,5-Difluorophenylboronic acid CAS 156545-07-2 is a useful fluorinated organic intermediate when a project requires a 3,5-difluorophenyl unit and a boronic acid coupling handle. The best purchasing decision depends on the complete technical specification, intended reaction, scale, documentation requirements, and supply schedule. A careful review of these factors can reduce avoidable qualification and delivery risks.

To begin, prepare your required quantity, target purity, packaging preference, destination, and documentation checklist. Contact Maison Chemical with these details so we can confirm current availability, MOQ, lead time, quotation conditions, and suitable product support for your application.

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