3,5-Dimethylphenylboronic acid, identified by CAS No. 172975-69-8, is an aromatic boronic acid used mainly as a building block in palladium-catalyzed cross-coupling and other synthetic research. For purchasing and project planning, I recommend evaluating four points first: chemical identity, assay and impurity profile, packaging and storage, and the supplier’s ability to provide consistent documentation. The compound has the molecular formula C8H11BO2 and a calculated molecular weight of approximately 149.98 g/mol. This guide explains how I would assess the material for laboratory, process-development, and commercial sourcing applications.
This guide is intended for pharmaceutical and agrochemical researchers, specialty chemical manufacturers, process-development teams, procurement professionals, and distributors sourcing organic boronic acids. It is also useful for buyers comparing small research quantities with larger project-based requirements. Because commercial specifications can differ by manufacturer and grade, I treat the information below as a purchasing framework rather than a replacement for a current certificate of analysis.
3,5-Dimethylphenylboronic acid contains a boronic acid group attached to an aromatic ring with methyl substituents at the 3 and 5 positions. Its structure makes it a useful aryl-boron reagent for forming carbon-carbon bonds, particularly when a substituted aryl fragment is required in a target molecule. In routine synthesis, the boronic acid group participates in reaction pathways that transfer the aryl group to a suitable coupling partner.
The compound is commonly handled as a solid research or production intermediate. Like many boronic acids, it should be protected from unnecessary exposure to moisture, heat, and contamination, because storage conditions and handling practices can influence material quality over time. I recommend confirming the supplier’s current storage instructions, appearance specification, and retest or review period before placing an order.
A reliable purchase specification should distinguish confirmed identity data from lot-specific quality results. The identity information for this product includes CAS No. 172975-69-8, molecular formula C8H11BO2, and molecular weight approximately 149.98 g/mol. Appearance, assay, water content, residual solvents, elemental impurities, and chromatographic impurity limits should be defined in the product specification or confirmed through the applicable certificate of analysis.
| Specification area | What buyers should confirm | Why it matters |
|---|---|---|
| Identity | CAS number, formula, molecular weight, and analytical identity data | Prevents substitution or incorrect positional isomer selection |
| Assay | Acceptance limit and analytical method, typically stated by the supplier | Supports reaction stoichiometry and batch consistency |
| Impurity profile | Related substances, residual solvents, water, and inorganic residues where relevant | Helps control downstream reaction performance and purification effort |
| Physical form | Color, form, packaging, and any caking or visual limits | Supports receiving inspection and handling decisions |
| Documentation | Certificate of analysis, safety data sheet, specification sheet, and lot information | Improves traceability and internal quality review |
I do not recommend assuming a universal purity value, melting point, or moisture limit from a catalog description alone. These values can vary according to grade, production route, analytical method, and customer specification. For a regulated or scale-up project, buyers should request a recent lot-specific certificate of analysis and clarify whether the stated assay is calculated on an as-is or dry basis.
In practice, buyers may encounter research-grade material, higher-purity project material, or custom-manufactured material supplied against an agreed specification. The chemical identity remains the same, but the acceptance limits, package size, testing scope, and documentation may differ. A small research pack may be suitable for route screening, while process development may require tighter controls on trace metals, water, residual solvents, and individual impurities.
For larger requirements, I suggest discussing whether the supplier can provide a consistent lot strategy rather than purchasing unrelated small packages. If the material will enter a multi-step synthesis, the buyer should also consider whether the supplier can support repeat orders, reserve production capacity, or provide a practical sample-to-bulk transition plan.
The primary application of 3,5-dimethylphenylboronic acid is as an aryl-boron reagent in cross-coupling chemistry. It can be paired with suitable aryl or vinyl halides, pseudohalides, and related coupling partners under a reaction system selected by the chemist. Actual conversion depends on the catalyst, base, solvent, temperature, substrate structure, water content, and work-up method, so I would not treat the reagent as a guarantee of reaction success.
The 3,5-dimethylphenyl group can be incorporated into medicinal chemistry compounds, advanced intermediates, and research molecules where that substitution pattern is required. It may be useful during analogue synthesis, structure-activity relationship studies, or route-development work. The final suitability depends on the target structure and the impurity controls required by the application.
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Contract manufacturers and research organizations may use this material when preparing substituted biaryl, heteroaryl, or other aromatic compounds. In these settings, the most important purchasing questions often concern repeatability, lead time, analytical support, and the supplier’s ability to match a project-specific specification. A technical discussion before ordering can reduce the risk of selecting a grade that is adequate for screening but unsuitable for scale-up.
Start by matching the name, CAS No. 172975-69-8, molecular formula, molecular weight, and structural position of the methyl groups. Positional isomers can have different reaction behavior and may not be interchangeable in a synthesis plan. I recommend reviewing the supplier’s identity data before comparing price.
For early screening, a standard research specification may be sufficient if the laboratory has an appropriate purification and analytical workflow. For process development or commercial intermediate production, buyers should define impurity limits, water control, residual solvent requirements, and traceability expectations in advance. The right specification is the one that supports the downstream process without creating unnecessary cost.
Ask how the material is packaged, whether the container provides suitable protection from moisture, and whether the supplier identifies the lot clearly. A conservative approach is to keep the product tightly closed in a cool, dry, and well-controlled storage area, following the supplier’s safety data sheet and label instructions. Any special storage requirement should be confirmed before shipment.
Price is only one part of total sourcing cost. I also assess minimum order quantity, sample availability, production lead time, export documentation, repeat-order capability, and communication speed. If a project depends on several kilograms or recurring supply, I recommend requesting a forecast-based quotation rather than relying only on a spot price.
Pricing for 3,5-dimethylphenylboronic acid can vary with quantity, purity, packaging, testing requirements, shipping destination, and market conditions. A small laboratory pack normally has a different unit economics profile from a larger project order. Buyers should request a quotation that clearly separates product price, packaging, transport, documentation, and any custom testing charges.
Minimum order quantity is also supplier-specific and may change between stock material and made-to-order production. For a new project, I suggest starting with a representative sample or small qualification quantity, then confirming the bulk specification before committing to a larger purchase. Lead time should be confirmed in writing because stock availability and production scheduling are not the same thing.
At Maison Chemical, I approach this product as a technical sourcing requirement rather than a simple catalog transaction. Our support can focus on confirming chemical identity, discussing the intended application, reviewing available quality documentation, and preparing a quotation according to quantity and destination. Buyers can contact our Chemicals team with the required quantity, target specification, packaging preference, and delivery location so that we can evaluate the most suitable supply route.
3,5-Dimethylphenylboronic acid CAS 172975-69-8 can be a practical choice when a synthesis requires a 3,5-dimethyl-substituted aryl building block, especially for cross-coupling and intermediate development. The safest purchasing decision is based on verified identity, an appropriate quality specification, controlled handling, and a supplier capable of supporting the project beyond a single shipment. I recommend requesting a current specification sheet, lot-specific certificate of analysis, safety documentation, quotation, MOQ, and lead-time information before approval.
To begin a sourcing discussion with Maison Chemical, prepare the expected quantity, intended use, required purity or impurity limits, packaging needs, and destination country. With those details, our team can help assess the suitable product grade and provide a practical B2B supply proposal without treating unverified assumptions as guaranteed performance.
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