3,4-Difluoro-2-methoxyphenylboronic acid, CAS 905583-06-4, is an aromatic boronic acid used primarily as a research and pharmaceutical-intermediate building block. Its key value is the aryl boronic acid group, which can participate in palladium-catalyzed Suzuki–Miyaura cross-coupling to introduce a substituted difluoromethoxyphenyl moiety into a target molecule. The compound is commonly evaluated by identity, assay, water content, residual solvents, inorganic impurities, and handling requirements rather than by a single universal commercial specification. At Maison Chemical, I recommend confirming the current specification, analytical package, packaging, MOQ, and lead time before placing a purchase order.
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The compound has the molecular formula C7H7BF2O3 and a calculated molecular weight of approximately 187.94 g/mol. These identity details should be checked against the supplier’s current certificate of analysis and safety data sheet because product records, test methods, and commercial grades may differ. PubChem is a useful public reference for confirming chemical identity and structure information, while the supplier remains responsible for batch-specific documentation.
Source: National Center for Biotechnology Information, PubChem, chemical information resources: pubchem.ncbi.nlm.nih.gov.
This guide is intended for pharmaceutical research organizations, medicinal chemistry teams, CROs, process-development laboratories, fine-chemical distributors, and procurement departments sourcing 3,4-difluoro-2-methoxyphenylboronic acid. It is also useful for buyers comparing catalog material with made-to-order or project-based supply. I focus on practical purchasing questions: what the compound is, where it may be used, which specifications matter, and how to assess a supplier.
The information is suitable for early-stage sourcing and technical discussions, but it does not replace a validated process, a product-specific SDS, or an application-specific risk assessment. Buyers should confirm whether the material is intended for research use, process development, or a regulated manufacturing route. The required documentation and quality controls normally become more demanding as the project moves toward scale-up and commercial production.
3,4-Difluoro-2-methoxyphenylboronic acid contains a substituted aromatic ring with two fluorine atoms, one methoxy group, and one boronic acid group. The boronic acid functionality is the principal synthetic handle, while the fluorine and methoxy substituents influence the electronic and steric environment of the aromatic ring. This combination can be useful when a project requires a specific substituted aryl fragment rather than an unsubstituted phenylboronic acid.
Its CAS Registry Number is 905583-06-4, and the approximate molecular weight is 187.94 g/mol. For procurement records, I recommend recording the CAS number, systematic or supplier name, molecular formula, molecular weight, structure representation, and internal material code together. This reduces the risk of confusing the compound with positional isomers or related difluoromethoxyphenylboronic acids.
Arylboronic acids are widely associated with Suzuki–Miyaura coupling, a cross-coupling method that combines an organoboron reagent with an aryl or vinyl electrophile in the presence of a suitable catalyst and reaction system. The actual performance depends on the substrate pair, catalyst, base, solvent, temperature, concentration, and work-up conditions. I therefore treat the compound as a valuable coupling building block, not as a guarantee of a particular yield or reaction outcome.
Organoboron compounds may be affected by moisture, prolonged storage, impurities, or unsuitable handling conditions. The correct storage temperature, packaging configuration, and shelf-life statement must come from the applicable supplier SDS, label, and batch documentation. Buyers should not assume that a storage range such as 2–8 °C is appropriate unless it is explicitly stated for the supplied material.
Source: Miyaura, N. and Suzuki, A., “Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds,” Chemical Reviews, 1995, 95, 2457–2483. This established review describes the reaction class and its dependence on reaction conditions.
Commercial supply may be offered in different quality and packaging formats rather than in fundamentally different chemical types. Typical purchasing categories include research-grade material, higher-purity development material, and custom or project-specific batches. The correct choice depends on the intended reaction, impurity tolerance, scale, regulatory expectations, and analytical documentation required by the buyer.
| Specification Area | What to Confirm | Why It Matters |
|---|---|---|
| Identity | CAS 905583-06-4, structure, formula, molecular weight, and analytical identity | Helps prevent positional-isomer or material-code errors |
| Assay | Test method, reported result, and whether the value is chromatographic purity or assay | Different terms may not describe the same measurement |
| Related substances | Known and unknown impurity profile, with reporting thresholds where applicable | Impurities can influence reaction development and downstream purification |
| Water content | Karl Fischer or another stated method, where relevant | Water may affect reagent handling and reaction reproducibility |
| Residual solvents | Solvent names, limits, and analytical method | Important for process development and quality review |
| Packaging | Primary container, closure, protective atmosphere if used, and pack size | Supports stability, transport, and inventory planning |
Do not treat a stated purity percentage as a complete quality profile. A product listed at 98% or 99% by HPLC may still require review of water, residual solvents, inorganic residues, and unidentified peaks. I recommend requesting the analytical method, chromatogram or representative data where available, and a batch-specific certificate of analysis before approving the material for a critical route.
In medicinal chemistry, this boronic acid can serve as a modular aryl fragment for assembling analogues through cross-coupling. The difluoro and methoxy substitution pattern may help researchers explore electronic, steric, lipophilic, or metabolic-property changes within a compound series. The usefulness of the building block should be assessed through the project’s actual reaction screen rather than inferred solely from the name or substituent pattern.
Process chemists may evaluate this material when comparing synthetic routes, catalyst systems, bases, solvents, and isolation methods. At this stage, consistent assay, controlled impurity levels, dependable lot traceability, and sufficient supply continuity are often more important than the lowest initial price. A buyer may also need a larger representative sample before committing to a multi-kilogram requirement.
For a defined pharmaceutical intermediate route, the buyer may require controlled change notification, a documented specification, batch numbering, and a supply agreement. The exact requirements depend on the customer’s quality system and intended use. Maison Chemical can discuss standard or custom supply routes, but I recommend finalizing acceptance criteria only after reviewing the customer’s process, analytical method, and documentation requirements.
With competitive price and timely delivery, Maison Chemical sincerely hope to be your supplier and partner.
Source: International Council for Harmonisation, ICH Q7, Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients. The guideline provides internationally recognized principles for material controls, documentation, testing, and supplier management: ich.org quality guidelines.
First, state whether the material is for route scouting, medicinal chemistry, process development, analytical reference work, or a regulated manufacturing step. This decision affects the required purity, documentation, pack size, and change-control expectations. It also prevents a buyer from over-specifying a research material or under-specifying a process-critical intermediate.
Ask for the current product specification and a representative or batch-specific certificate of analysis. Confirm the identity method, assay or purity method, water test, residual-solvent controls, elemental or inorganic impurity controls where relevant, and the treatment of unknown impurities. If the compound is used in a sensitive coupling reaction, discuss whether the supplier can provide additional information on boron-containing or metal-related impurities.
Request the SDS, label information, recommended storage conditions, shelf-life or retest statement, and transport instructions. Confirm whether the packaging is suitable for the requested quantity, such as 1 g, 10 g, 100 g, or a larger development batch. These quantities are examples of common purchasing discussions, not a guaranteed Maison Chemical pack-size list.
Obtain a written quotation that separates unit price, packaging, testing, shipping, and any custom-development charges. Ask whether the quoted MOQ is based on an existing stock lot, a production batch, or a custom synthesis campaign. Lead time should be confirmed in calendar days or business days and should include the time required for testing and release.
Pricing for this type of specialty intermediate can vary with purity, quantity, synthesis route, raw-material availability, packaging, analytical requirements, and destination. I avoid presenting a universal price because a public catalog price may not represent a development-scale or production-scale quotation. A reliable request for quotation should include the target quantity, delivery country, required Incoterm, specification, packaging preference, and desired delivery date.
Source: International Chamber of Commerce, Incoterms® rules, which explain the allocation of delivery responsibilities, costs, and risks in international trade: iccwbo.org/business-solutions/incoterms-rules.
A supplier’s ability to answer these questions is often more useful than a low headline price. Buyers should compare quotations on a like-for-like basis, including assay method, impurity limits, documentation, pack size, delivery terms, and release timing. For a route-critical material, continuity planning and transparent communication may reduce sourcing risk even when the initial unit price is not the lowest.
One common mistake is ordering by name alone without checking the structure and CAS number. Another is comparing a supplier’s HPLC purity value with a different supplier’s assay value as though the two results were directly equivalent. Buyers also sometimes request a quotation without stating the required quantity, delivery location, or documentation package, which can lead to a quotation that is difficult to compare.
Storage assumptions are another avoidable issue. A buyer should follow the product-specific SDS and label instead of applying a generic condition to every boronic acid. Finally, a small research sample does not automatically demonstrate suitability for scale-up, so process teams should plan a representative-lot evaluation before locking the material into a larger campaign.
At Maison Chemical, I approach this product as a technical sourcing project rather than a simple catalog transaction. We can help clarify the required quantity, target specification, packaging, documentation, and delivery destination before preparing a quotation. Depending on the project, the discussion may include sample supply, standard material, custom batch planning, analytical documentation, and staged procurement.
To receive a practical quotation, please provide the requested quantity, purity or impurity requirements, intended application, packaging preference, destination country, target delivery date, and any required documents. If you have an internal specification or analytical method, sharing it at the inquiry stage can reduce clarification time. We will then review feasibility and respond with the applicable commercial and technical details rather than making unsupported assumptions.
3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 can be a useful pharmaceutical and fine-chemical intermediate when a project needs a defined difluoromethoxy-substituted aryl building block. The right purchasing decision depends on confirmed identity, fit-for-purpose purity, analytical documentation, handling requirements, supply quantity, and route-specific performance. No universal specification, price, MOQ, or lead time should be accepted without a product-specific quotation and documentation review.
My recommended next step is to send Maison Chemical your target quantity, intended use, required specification, delivery location, and documentation expectations. We can then assess sample or production supply, align the certificate of analysis requirements, and provide a quotation based on your actual project conditions. This approach gives procurement and technical teams a clearer basis for approving the material and planning the next stage of development.
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