4-Aminophenylboronic acid listed under CAS 214360-73-3 is generally associated with the protected boronic acid intermediate commonly known as 4-aminophenylboronic acid pinacol ester. The name “picol ester” should be confirmed before purchasing because “pinacol ester” and “picol ester” can describe different chemical structures. I recommend verifying the product name, CAS number, molecular formula, structure, and analytical documentation together rather than relying on the name alone.
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For procurement and research planning, this compound is typically considered an aromatic boronate ester containing both an aniline amino group and a boron-containing coupling handle. Its commonly reported molecular formula is C12H18BNO2, with a molecular weight of approximately 219.09 g/mol. It is mainly used as a synthetic building block for Suzuki–Miyaura coupling and related organic synthesis, subject to the customer’s validated reaction conditions and quality requirements.
The molecule combines a para-aminophenyl group with a protected boronic ester functionality. The amino group can participate in further functionalization, protection, salt formation, or linkage-building chemistry, while the boronate ester can act as a partner in palladium-catalyzed carbon–carbon bond formation. This dual functionality makes the intermediate useful when a synthesis requires both an aryl coupling site and a modifiable aromatic amine.
In the form most often associated with CAS 214360-73-3, the boron center is protected as a cyclic pinacol boronate ester. This protection can improve handling and compatibility compared with some unprotected boronic acids, although hydrolysis and degradation behavior still depend on water exposure, pH, temperature, solvent, and storage conditions. I therefore treat the exact structural assignment as a critical purchasing checkpoint.
Commercial records may contain variations such as “4-aminophenylboronic acid pinacol ester,” “4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline,” or abbreviated forms such as “4-aminophenyl-Bpin.” The supplied description uses “picol ester,” which may be a naming variation or a typographical substitution for “pinacol ester.” Before placing an order, I recommend comparing the supplier’s structure image and certificate of analysis with CAS 214360-73-3.
The principal synthetic application is as an aryl boronate reagent for coupling with suitable aryl or heteroaryl halides. These reactions can generate biaryl or heteroaryl–aryl frameworks found in medicinal chemistry, agrochemical research, materials development, and intermediate synthesis. Actual performance depends on the catalyst, base, solvent, temperature, substrate compatibility, and control of moisture or oxygen.
The para-amino group provides an additional point for downstream chemistry. Researchers may protect the amine before coupling when the free amino group interferes with catalyst coordination, solubility, or selectivity. In other routes, the unprotected amine is retained for subsequent acylation, urea formation, sulfonamide formation, or other derivatization steps.
In discovery chemistry, this compound can support rapid construction of substituted aromatic libraries. A coupling reaction can install a second aromatic or heteroaromatic fragment, after which the amino group can be modified to tune polarity, hydrogen bonding, or biological activity. I would describe these as research and synthesis uses rather than guaranteed end-use outcomes, because suitability must be established experimentally for each route.
The same structural features can also be relevant to functional organic materials and ligand-related synthesis. However, buyers should not assume that a research-grade material is automatically suitable for regulated manufacturing, electronic applications, or clinical-stage production. Those uses require a separate assessment of impurities, trace metals, analytical methods, change control, and documentation.
CAS 214360-73-3 is associated with a solid organic boronate ester, but appearance, particle size, color, and stability should be confirmed from the current batch documentation. A typical product specification may include identity by techniques such as NMR, mass spectrometry, or infrared analysis, together with chromatographic purity and water content. The exact acceptance limits should be agreed before commercial supply rather than inferred from a catalog title.
| Item | Procurement relevance |
|---|---|
| CAS number | 214360-73-3; confirm against the structure and supplier documentation |
| Commonly associated formula | C12H18BNO2 |
| Approximate molecular weight | 219.09 g/mol |
| Suggested purity discussion | Request a defined limit, such as ≥98%, only when appropriate for the intended route |
| Packaging and storage | Confirm container, atmosphere, temperature, and shelf-life guidance from the SDS and CoA |
The value of a specification is not the number alone; it is the analytical method behind that number. For example, “98%” is incomplete unless the buyer knows whether it refers to HPLC area percentage, assay by another method, or a different measurement basis. I recommend requesting the current CoA, analytical method summary, residual solvent information where relevant, and an impurity profile proportionate to the application.
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Buyers may encounter several related options, including the free boronic acid, the pinacol ester, other cyclic boronate esters, and protected amino derivatives. These are not interchangeable solely because they contain the same aromatic ring. Their solubility, hydrolytic behavior, reactivity, handling requirements, and compatibility with the next reaction can differ.
The pinacol ester is often selected when the synthesis benefits from a protected boron functionality and a defined, isolable intermediate. The free boronic acid may be preferred in some aqueous or hydrolysis-driven processes, while an N-protected amino derivative may be more suitable when the amine must remain inactive during coupling. I suggest selecting the form according to the complete reaction sequence, not only the first transformation.
If the project uses a different “picol” structure, the buyer should request a structural drawing, molecular formula, molecular weight, and a representative analytical package. A mismatch between the requested name and CAS number can lead to incorrect reaction calculations, customs documentation, or failed route validation. Maison Chemical can review these identifiers before quotation to reduce avoidable sourcing errors.
For laboratory screening, identity and purity may be the primary requirements. For process development, buyers commonly need tighter control of water, residual solvents, related substances, trace metals, and batch-to-batch consistency. For scale-up, I also recommend discussing analytical sampling, retest or shelf-life expectations, packaging configuration, and notification procedures for material or process changes.
Order quantity should match the stage of the project. A small evaluation quantity can support identity and reaction screening, while larger quantities require confirmation of production capacity, packaging suitability, export documents, and release timing. Lead time, minimum order quantity, and shipping conditions should be quoted for the requested grade and quantity because they can vary by batch availability and destination.
Storage instructions should be taken from the supplier’s SDS and product documentation. I avoid giving a universal temperature or shelf-life claim without batch-specific evidence, because boronate esters may respond differently to moisture, heat, and repeated container opening. Buyers should also confirm whether the packaging is suitable for the planned transit duration and local handling requirements.
At Maison Chemical, I approach this product as a specification-matching and supply-planning project rather than a simple catalog transaction. We can help review the CAS number, structure, requested grade, intended application, quantity, packaging, and destination before preparing a quotation. This is particularly important when the request uses “picol ester” while the CAS record is commonly connected with the pinacol ester name.
For a meaningful inquiry, please provide the required quantity, target purity, preferred analytical documentation, application stage, delivery location, and desired timeline. If you have a structure file, internal specification, or existing CoA, sharing it can help us confirm whether the requested material is chemically aligned. We can then discuss available supply, production or sourcing arrangements, packaging, export documentation, and practical next steps without making unsupported claims about suitability.
4-Aminophenylboronic acid associated with CAS 214360-73-3 is a useful aromatic boronate intermediate when a synthesis requires both a coupling handle and a para-amino functionality. The most important immediate action is to confirm whether the project requires the pinacol ester generally linked to this CAS number or a different compound described as a picol ester. After that confirmation, the buyer should align purity, analytical testing, packaging, quantity, and delivery requirements with the intended route.
Maison Chemical can support the next step by reviewing your specification and preparing a supply response based on the required grade and volume. Send us the CAS number, structure or product description, quantity, target purity, destination, and documentation requirements. We will use those details to help clarify product identity and develop a practical B2B quotation pathway.
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